Saw this xkcd comic and immediately thought of Wittgenstein's oh-so-modest introduction to the Tractatus Logico-Philosophicus:
On the other hand the truth of the thoughts communicated here seems to me unassailable and definitive. I am, therefore, of the opinion that the problems have in essentials been finally solved. And if I am not mistaken in this, then the value of this work secondly consists in the fact that it shows how little has been done when these problems have been solved.